/* ============================================================
   Myra EB — v1 stylesheet
   Design system per design.md ("Runway" style reference)
   Monochrome editorial. No shadows. No gradients.
   Monochrome throughout; no chromatic accent in use.
   ============================================================ */

:root {
  /* Colors */
  --color-ink-black: #0c0c0c;
  --color-carbon: #1a1a1a;
  --color-graphite: #2a2a2a;
  --color-slate: #404040;
  --color-steel: #6b7280;
  --color-silver: #999999;
  --color-bone: #e5e7eb;
  --color-cloud: #eef1f5;
  --color-pure-white: #ffffff;
  --color-cobalt-signal: #2b22fa;

  /* Typography — abcNormal / Söhne are licensed; Inter Tight is the
     variable-weight stand-in so weight 450 remains available. */
  --font-abcnormal: 'abcNormal', 'Söhne', 'Inter Tight', ui-sans-serif, system-ui,
    -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, sans-serif;

  /* Type scale */
  --text-caption: 11px;      --leading-caption: 1.43;      --tracking-caption: 0.28px;
  --text-body: 14px;         --leading-body: 1.5;          --tracking-body: -0.07px;
  --text-body-lg: 16px;      --leading-body-lg: 1.5;       --tracking-body-lg: -0.1px;
  --text-subheading: 20px;   --leading-subheading: 1.3;    --tracking-subheading: -0.12px;
  --text-heading-sm: 24px;   --leading-heading-sm: 1.25;   --tracking-heading-sm: -0.24px;
  --text-heading: 36px;      --leading-heading: 1.1;       --tracking-heading: -0.6px;
  --text-heading-lg: 40px;   --leading-heading-lg: 1.1;    --tracking-heading-lg: -0.96px;
  --text-display: 48px;      --leading-display: 1;         --tracking-display: -1.2px;

  /* Weights */
  --fw-regular: 400;
  --fw-450: 450;
  --fw-medium: 500;
  --fw-semibold: 600;

  /* Spacing */
  --spacing-4: 4px;    --spacing-8: 8px;    --spacing-12: 12px;  --spacing-16: 16px;
  --spacing-20: 20px;  --spacing-24: 24px;  --spacing-28: 28px;  --spacing-40: 40px;
  --spacing-48: 48px;  --spacing-64: 64px;  --spacing-80: 80px;  --spacing-96: 96px;
  --spacing-160: 160px; --spacing-176: 176px; --spacing-240: 240px;

  /* Layout */
  --page-max-width: 1200px;
  --page-gutter: 24px;
  --section-gap: 72px;

  /* Radius */
  --radius-tags: 4px;
  --radius-cards: 0px;
  --radius-images: 0px;
  --radius-inputs: 8px;
  --radius-buttons: 8px;

  /* Surfaces */
  --surface-page-canvas: #ffffff;
  --surface-soft-wash: #eef1f5;
}

/* ---------- Reset ---------- */
*, *::before, *::after { box-sizing: border-box; }
html { -webkit-text-size-adjust: 100%; }
body {
  margin: 0;
  background: var(--surface-page-canvas);
  color: var(--color-ink-black);
  font-family: var(--font-abcnormal);
  font-size: var(--text-body-lg);
  line-height: var(--leading-body-lg);
  letter-spacing: var(--tracking-body-lg);
  font-weight: var(--fw-regular);
  -webkit-font-smoothing: antialiased;
  text-rendering: optimizeLegibility;
}
img, svg, video { display: block; max-width: 100%; height: auto; }
h1, h2, h3, h4, p, figure, ul, ol { margin: 0; }
ul, ol { padding: 0; list-style: none; }
button { font: inherit; color: inherit; background: none; border: 0; padding: 0; cursor: pointer; }
a { color: inherit; text-decoration: none; }
table { border-collapse: collapse; width: 100%; }

/* ---------- Layout primitives ---------- */
.wrap {
  max-width: var(--page-max-width);
  margin-inline: auto;
  padding-inline: var(--page-gutter);
}
.section { padding-block: var(--section-gap); }
.section--tight { padding-block: var(--spacing-48); }
.hairline { border: 0; border-top: 1px solid var(--color-bone); margin: 0; }
.stack > * + * { margin-top: var(--spacing-16); }

/* ---------- Type ---------- */
.display {
  font-size: var(--text-display);
  line-height: var(--leading-display);
  letter-spacing: var(--tracking-display);
  font-weight: var(--fw-450);
  color: var(--color-ink-black);
  max-width: 1040px;
  text-wrap: balance;
}
.heading-lg {
  font-size: var(--text-heading-lg);
  line-height: var(--leading-heading-lg);
  letter-spacing: var(--tracking-heading-lg);
  font-weight: var(--fw-regular);
  max-width: 900px;
}
.heading {
  font-size: var(--text-heading);
  line-height: var(--leading-heading);
  letter-spacing: var(--tracking-heading);
  font-weight: var(--fw-regular);
  max-width: 720px;
}
.heading-sm {
  font-size: var(--text-heading-sm);
  line-height: var(--leading-heading-sm);
  letter-spacing: var(--tracking-heading-sm);
  font-weight: var(--fw-450);
}
.subheading {
  font-size: var(--text-subheading);
  line-height: var(--leading-subheading);
  letter-spacing: var(--tracking-subheading);
  font-weight: var(--fw-medium);
}
.body { font-size: var(--text-body-lg); line-height: var(--leading-body-lg); letter-spacing: var(--tracking-body-lg); color: var(--color-slate); max-width: 68ch; }
.body-sm { font-size: var(--text-body); line-height: var(--leading-body); letter-spacing: var(--tracking-body); color: var(--color-slate); }
.caption {
  font-size: var(--text-caption);
  line-height: var(--leading-caption);
  letter-spacing: var(--tracking-caption);
  text-transform: uppercase;
  color: var(--color-steel);
  font-weight: var(--fw-medium);
}
.muted { color: var(--color-slate); }
.eyebrow { display: block; margin-bottom: var(--spacing-24); }

/* Inline underlined link */
.link-inline {
  text-decoration: underline;
  text-underline-offset: 2px;
  text-decoration-thickness: 1px;
}
.link-inline:hover { text-decoration-thickness: 2px; }

/* ---------- Navigation ---------- */
.nav {
  position: sticky;
  top: 0;
  z-index: 50;
  background: var(--color-pure-white);
  border-bottom: 1px solid var(--color-bone);
}
/* Nav spans the full viewport with its own gutters, so the logo sits near the
   left edge instead of being pulled inward by the 1200px content column. */
.nav .wrap { max-width: none; padding-inline: var(--spacing-28); }
.nav__inner {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: var(--spacing-24);
  height: 60px;
}
.wordmark {
  display: inline-flex;
  align-items: center;
  gap: var(--spacing-8);
  color: var(--color-ink-black);
  white-space: nowrap;
}
.wordmark__mark { width: 22px; height: 22px; flex: none; display: block; object-fit: contain; }
.wordmark__text {
  font-size: 15px;
  line-height: 1;
  font-weight: var(--fw-medium);
  letter-spacing: 0.05em;
  text-transform: uppercase;
}
.footer .wordmark__mark { width: 20px; height: 20px; }
.footer .wordmark__text { font-size: 14px; }
.nav__links {
  display: flex;
  align-items: stretch;
  gap: var(--spacing-20);
  align-self: stretch;
}
.nav__links > a { display: flex; align-items: center; }

/* Hover menu: a nav item that reveals its page's sections */
.nav__item { position: relative; display: flex; align-items: center; }
.nav__menu {
  position: absolute;
  top: 100%;
  left: calc(var(--spacing-20) * -1);
  min-width: 240px;
  background: var(--color-pure-white);
  border: 1px solid var(--color-bone);
  border-top: 0;
  opacity: 0;
  visibility: hidden;
  transform: translateY(-2px);
  transition: opacity 120ms ease, transform 120ms ease, visibility 120ms;
}
.nav__item:hover .nav__menu,
.nav__item:focus-within .nav__menu {
  opacity: 1;
  visibility: visible;
  transform: translateY(0);
}
.nav__menu-inner { padding: var(--spacing-12) 0; }
.nav__menu a {
  display: block;
  padding: var(--spacing-8) var(--spacing-20);
  font-size: var(--text-body);
  line-height: var(--leading-body);
  letter-spacing: var(--tracking-body);
  font-weight: var(--fw-450);
  text-transform: none;
  color: var(--color-slate);
  white-space: nowrap;
}
.nav__menu a:hover { color: var(--color-ink-black); background: var(--surface-soft-wash); }
.nav__links a:not(.nav__menu a) {
  font-size: 13px;
  font-weight: var(--fw-medium);
  letter-spacing: 0.02em;
  text-transform: uppercase;
  color: var(--color-ink-black);
}
.nav__links a:hover { color: var(--color-slate); }
.nav__links a[aria-current="page"] { text-decoration: underline; text-underline-offset: 6px; text-decoration-thickness: 1px; }
.nav__actions { display: flex; align-items: center; gap: var(--spacing-20); }

/* Mobile nav */
.nav__toggle { display: none; font-size: 13px; font-weight: var(--fw-medium); text-transform: uppercase; letter-spacing: 0.02em; }
.nav__mobile { display: none; border-top: 1px solid var(--color-bone); }
.nav__mobile.is-open { display: block; }
.nav__mobile a {
  display: block;
  padding: var(--spacing-12) 0;
  font-size: 13px;
  font-weight: var(--fw-medium);
  text-transform: uppercase;
  letter-spacing: 0.02em;
  border-bottom: 1px solid var(--color-bone);
}
.nav__mobile a:last-child { border-bottom: 0; }
.nav__mobile a.nav__mobile-sub {
  padding-left: var(--spacing-20);
  text-transform: none;
  font-weight: var(--fw-450);
  color: var(--color-slate);
}

/* ---------- Buttons & links ---------- */
.btn {
  display: inline-flex;
  align-items: center;
  gap: var(--spacing-8);
  font-size: var(--text-body);
  font-weight: var(--fw-medium);
  letter-spacing: var(--tracking-body);
  white-space: nowrap;
}
.btn--dark {
  background: var(--color-ink-black);
  color: var(--color-pure-white);
  border-radius: var(--radius-buttons);
  padding: 10px 20px;
}
.btn--dark:hover { background: var(--color-graphite); }
.btn--pill {
  background: var(--color-carbon);
  color: var(--color-pure-white);
  border-radius: var(--radius-buttons);
  padding: 10px 18px;
}
.btn--pill:hover { background: var(--color-graphite); }
.btn--ghost { color: var(--color-ink-black); padding: var(--spacing-8) 0; }
.btn--ghost:hover { color: var(--color-slate); }
.btn--ghost .arrow { transition: transform 140ms ease; }
.btn--ghost:hover .arrow { transform: translateX(4px); }
.link-ghost {
  font-size: 13px;
  font-weight: var(--fw-medium);
  color: var(--color-ink-black);
}
.link-ghost:hover { color: var(--color-slate); }

/* ---------- Media placeholders ----------
   Swap these for real <img>/<video>. Sharp corners, flat, no shadow. */
.media {
  position: relative;
  width: 100%;
  background: var(--surface-soft-wash);
  border-radius: var(--radius-images);
  overflow: hidden;
}
.media::after {
  content: attr(data-label);
  position: absolute;
  inset: 0;
  display: flex;
  align-items: center;
  justify-content: center;
  padding: var(--spacing-24);
  text-align: center;
  font-size: var(--text-caption);
  letter-spacing: var(--tracking-caption);
  text-transform: uppercase;
  color: var(--color-silver);
  font-weight: var(--fw-medium);
}
.media img, .media video { width: 100%; height: 100%; object-fit: cover; }
.media.is-filled { background: transparent; }
.media.is-filled::after { content: none; }
.media--wide   { aspect-ratio: 21 / 9; }
.media--video  { aspect-ratio: 16 / 9; }
.media--card   { aspect-ratio: 4 / 3; }
.media--figure { aspect-ratio: 3 / 2; }
.media--square { aspect-ratio: 1 / 1; }
.media--portrait { aspect-ratio: 3 / 4; }
.bleed { max-width: none; width: 100%; }

/* ---------- Hero ---------- */
.hero { padding-top: var(--spacing-160); padding-bottom: var(--spacing-96); }
.hero__actions { display: flex; align-items: center; gap: var(--spacing-24); margin-top: var(--spacing-40); }

/* Home: full-bleed graphic sits directly under the nav, edge to edge,
   so the page opens on the visual rather than on white space. */
.hero-media { width: 100%; }
.media--hero {
  aspect-ratio: 21 / 9;
  min-height: 220px;
  /* Cap the graphic so the hero statement and its link always clear the fold:
     viewport minus the nav and the full text block. */
  max-height: calc(100vh - 320px);
  max-height: calc(100svh - 320px);
}
.hero--after-media { padding-top: var(--spacing-48); padding-bottom: var(--spacing-96); }

/* ---------- Trust / affiliation strip ---------- */
.strip { padding-block: var(--spacing-40); }
.strip__row {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: var(--spacing-48);
  flex-wrap: wrap;
}
.strip__logo {
  color: var(--color-silver);
  font-size: var(--text-body);
  font-weight: var(--fw-medium);
  letter-spacing: 0.04em;
  text-transform: uppercase;
  filter: grayscale(1);
}

/* ---------- Card grid ---------- */
.grid-2 { display: grid; grid-template-columns: repeat(2, 1fr); gap: var(--spacing-24); }
.grid-3 { display: grid; grid-template-columns: repeat(3, 1fr); gap: var(--spacing-24); }
.grid-4 { display: grid; grid-template-columns: repeat(4, 1fr); gap: var(--spacing-24); }
.card { display: block; }
.card__title { margin-top: var(--spacing-16); font-size: var(--text-subheading); line-height: var(--leading-subheading); letter-spacing: var(--tracking-subheading); font-weight: var(--fw-medium); }
.card__desc { margin-top: var(--spacing-8); font-size: var(--text-body); line-height: var(--leading-body); letter-spacing: var(--tracking-body); color: var(--color-slate); }
a.card:hover .card__title { color: var(--color-slate); }

/* ---------- Alternating feature rows ---------- */
.feature {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: var(--spacing-48);
  align-items: center;
  padding-block: var(--spacing-80);
}
.feature--reverse .feature__media { order: 2; }
.feature--solo { grid-template-columns: minmax(0, 7fr) minmax(0, 5fr); }
.feature--stack { grid-template-columns: 1fr; }
.feature__body > * + * { margin-top: var(--spacing-24); }


/* Full-bleed image band: breaks a long editorial page */
.bleed-band { width: 100%; margin-block: var(--spacing-24); }
.bleed-band img { width: 100%; height: clamp(240px, 34vw, 420px); object-fit: cover; display: block; }

/* ---------- Section label ----------
   The label sits above its content. Content always begins at the left margin,
   so the eye starts where it expects to. */
.rail { display: block; }
.rail__label { margin-bottom: var(--spacing-24); }
.rail__label .caption { display: block; }
.rail__body > * + * { margin-top: var(--spacing-20); }
.rail__body > h2 + p, .rail__body > h3 + p { margin-top: var(--spacing-24); }

/* Heading left, prose right — the other half of the rhythm */
.split { display: grid; grid-template-columns: minmax(0, 5fr) minmax(0, 7fr); gap: var(--spacing-64); align-items: start; }
.split__head h2 { max-width: 20ch; }
.split__body > * + * { margin-top: var(--spacing-16); }
.split__body .body { max-width: 68ch; }
.split__body .prose-2, .feature__body .prose-2, .download__body .prose-2 { grid-template-columns: 1fr; gap: var(--spacing-16); }
.split__body .stats { grid-template-columns: repeat(2, minmax(0, 1fr)); gap: var(--spacing-28) var(--spacing-24); }

/* Two-up prose: fills the width without stretching line length */
.prose-2 { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: var(--spacing-40); }
.prose-2 .body { max-width: none; }
.prose-2 > * + * { margin-top: 0; }

/* ---------- Patient journey ---------- */
.journey {
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  gap: var(--spacing-24);
  margin-top: var(--spacing-64);
}
.journey__step { border-top: 1px solid var(--color-ink-black); padding-top: var(--spacing-16); }
.journey__num {
  display: block;
  font-size: var(--text-caption);
  letter-spacing: var(--tracking-caption);
  color: var(--color-steel);
  font-weight: var(--fw-medium);
}
.journey__title {
  margin-top: var(--spacing-12);
  font-size: var(--text-subheading);
  line-height: var(--leading-subheading);
  letter-spacing: var(--tracking-subheading);
  font-weight: var(--fw-medium);
}
.journey__body {
  margin-top: var(--spacing-8);
  font-size: var(--text-body);
  line-height: var(--leading-body);
  letter-spacing: var(--tracking-body);
  color: var(--color-slate);
}

/* ---------- Anchor targets ---------- */
[id] { scroll-margin-top: 84px; }

/* ---------- Page header ---------- */
.page-head { padding-top: var(--spacing-64); padding-bottom: var(--spacing-40); }
.section:first-of-type { padding-top: var(--spacing-48); }

/* ---------- Leadership ---------- */
.leaders { display: grid; grid-template-columns: repeat(3, 1fr); gap: var(--spacing-48) var(--spacing-24); }
.leader__toggle {
  display: block;
  width: 100%;
  text-align: left;
  margin-top: var(--spacing-16);
}
.leader__name { display: block; font-size: var(--text-subheading); line-height: var(--leading-subheading); letter-spacing: var(--tracking-subheading); font-weight: var(--fw-medium); }
.leader__role { display: block; margin-top: var(--spacing-4); font-size: var(--text-body); color: var(--color-slate); letter-spacing: var(--tracking-body); }
.leader__cue {
  margin-top: var(--spacing-12);
  display: inline-flex;
  align-items: center;
  gap: var(--spacing-8);
  font-size: 13px;
  font-weight: var(--fw-medium);
  color: var(--color-ink-black);
}
.leader__cue .sign { display: inline-block; width: 10px; }
.leader__bio { display: none; margin-top: var(--spacing-16); padding-top: var(--spacing-16); border-top: 1px solid var(--color-bone); }
.leader.is-open .leader__bio { display: block; }
.leader__toggle:hover .leader__name { color: var(--color-slate); }

/* Text-only bios: consultants and advisors, no portrait */
.leaders--text { grid-template-columns: repeat(2, minmax(0, 1fr)); gap: var(--spacing-28) var(--spacing-48); }
.leader--text { border-top: 1px solid var(--color-bone); padding-top: var(--spacing-16); }
.leader--text .leader__toggle { margin-top: 0; }

/* ---------- Pipeline chart ---------- */
.pipeline { width: 100%; }
.pipeline__head, .pipeline__row {
  display: grid;
  grid-template-columns: 220px 1fr;
  gap: var(--spacing-24);
  align-items: center;
}
.pipeline__head { padding-bottom: var(--spacing-12); border-bottom: 1px solid var(--color-ink-black); }
.pipeline__stages { display: grid; grid-template-columns: repeat(5, 1fr); }
.pipeline__stage { font-size: var(--text-caption); letter-spacing: var(--tracking-caption); text-transform: uppercase; color: var(--color-steel); font-weight: var(--fw-medium); }
.pipeline__row { padding-block: var(--spacing-28); border-bottom: 1px solid var(--color-bone); }
.pipeline__group { padding-top: var(--spacing-28); padding-bottom: var(--spacing-8); }
.pipeline__program { }
.pipeline__name { font-size: var(--text-subheading); line-height: var(--leading-subheading); letter-spacing: var(--tracking-subheading); font-weight: var(--fw-medium); }
.pipeline__meta { margin-top: var(--spacing-4); font-size: var(--text-body); color: var(--color-slate); letter-spacing: var(--tracking-body); }
.pipeline__track { position: relative; height: 28px; }
.pipeline__grid {
  position: absolute;
  inset: 0;
  display: grid;
  grid-template-columns: repeat(5, 1fr);
}
.pipeline__grid span { border-left: 1px solid var(--color-bone); }
.pipeline__grid span:first-child { border-left: 0; }
.pipeline__bar {
  position: absolute;
  top: 4px;
  bottom: 4px;
  left: 0;
  background: var(--color-ink-black);
}
.pipeline__bar--muted { background: var(--color-slate); }
.pipeline__legend { display: flex; gap: var(--spacing-24); flex-wrap: wrap; margin-top: var(--spacing-24); }
.pipeline__key { display: inline-flex; align-items: center; gap: var(--spacing-8); }
.pipeline__swatch { width: 20px; height: 8px; background: var(--color-ink-black); }
.pipeline__swatch--muted { background: var(--color-slate); }

/* ---------- Data table ---------- */
.dtable-scroll { overflow-x: auto; }
.dtable { width: 100%; min-width: 900px; border-collapse: collapse; }
.dtable th {
  text-align: left;
  vertical-align: bottom;
  padding: 0 var(--spacing-20) var(--spacing-12) 0;
  border-bottom: 1px solid var(--color-ink-black);
  font-size: var(--text-caption);
  line-height: var(--leading-caption);
  letter-spacing: var(--tracking-caption);
  text-transform: uppercase;
  color: var(--color-steel);
  font-weight: var(--fw-medium);
}
.dtable td {
  vertical-align: top;
  padding: var(--spacing-20) var(--spacing-20) var(--spacing-20) 0;
  border-bottom: 1px solid var(--color-bone);
  font-size: var(--text-body);
  line-height: var(--leading-body);
  letter-spacing: var(--tracking-body);
  color: var(--color-slate);
}
.dtable td strong { color: var(--color-ink-black); font-weight: var(--fw-medium); }
.dtable th:last-child, .dtable td:last-child { padding-right: 0; }

/* ---------- Footnotes ---------- */
.notes { margin-top: var(--spacing-40); max-width: 900px; }
.note {
  font-size: var(--text-caption);
  line-height: 1.55;
  letter-spacing: var(--tracking-caption);
  color: var(--color-steel);
  text-transform: none;
  max-width: 92ch;
}
.note + .note { margin-top: var(--spacing-12); }

/* ---------- Figure pair (comparison) ---------- */
.compare { display: grid; grid-template-columns: repeat(2, 1fr); gap: var(--spacing-24); margin-top: var(--spacing-48); }
.compare__cell { border-top: 1px solid var(--color-ink-black); padding-top: var(--spacing-16); }
.compare__value {
  font-size: var(--text-heading-lg);
  line-height: var(--leading-heading-lg);
  letter-spacing: var(--tracking-heading-lg);
  font-weight: var(--fw-regular);
}
.compare__label { margin-top: var(--spacing-8); font-size: var(--text-body); color: var(--color-slate); letter-spacing: var(--tracking-body); }
.compare__cell--muted .compare__value { color: var(--color-slate); }


/* ---------- Figures: charts and diagrams ---------- */
.figure { margin: 0; }
.figure__head { margin-bottom: var(--spacing-28); }
.figure__sub {
  margin-top: var(--spacing-8);
  font-size: var(--text-body);
  line-height: var(--leading-body);
  letter-spacing: var(--tracking-body);
  color: var(--color-steel);
}

/* Horizontal bar chart */
.barchart { display: grid; gap: var(--spacing-16); }
.bar { display: grid; grid-template-columns: 260px 1fr 80px; gap: var(--spacing-20); align-items: center; }
.bar__label {
  font-size: var(--text-body);
  line-height: 1.3;
  letter-spacing: var(--tracking-body);
  color: var(--color-ink-black);
}
.bar__note { display: block; font-size: var(--text-caption); letter-spacing: var(--tracking-caption); color: var(--color-steel); }
.bar__track { position: relative; height: 22px; border-left: 1px solid var(--color-bone); }
.bar__fill {
  height: 100%;
  background: var(--color-ink-black);
  border-radius: 0 var(--radius-tags) var(--radius-tags) 0;
  min-width: 2px;
  transition: opacity 120ms ease;
}
.bar__fill--study { background: var(--color-silver); }
.bar__fill--lit { background: #c8cbd0; }
.bar:hover .bar__fill { opacity: 0.75; }
.bar__value {
  font-size: var(--text-body);
  letter-spacing: var(--tracking-body);
  color: var(--color-slate);
  text-align: right;
  font-variant-numeric: tabular-nums;
}
.bar__value--lead { color: var(--color-ink-black); font-weight: var(--fw-medium); }
.bar--axis { margin-top: var(--spacing-4); }
.bar__axis {
  display: flex;
  justify-content: space-between;
  height: auto;
  border-left: 0;
  border-top: 1px solid var(--color-bone);
  padding-top: var(--spacing-8);
}
.bar__axis span { font-size: var(--text-caption); letter-spacing: var(--tracking-caption); color: var(--color-steel); }

.chart-legend { display: flex; flex-wrap: wrap; gap: var(--spacing-24); margin-top: var(--spacing-28); }

/* ---------- Illustration labels ----------
   The illustrations carry no baked-in type, so every term an image names is
   set here in HTML instead. Keeps the terminology correct and translatable. */
/* A standalone plate: image, its keys, then its caption, held to a readable
   width. Full-bleed artwork swamps the text that has to explain it. */
.figure--plate { max-width: 760px; margin-top: var(--spacing-40); }
.figure--plate .fig-keys { margin-top: var(--spacing-16); }
.figure--plate .note { margin-top: var(--spacing-16); }

.fig-keys { display: flex; flex-wrap: wrap; align-items: baseline; gap: var(--spacing-12); margin-top: var(--spacing-20); }
.fig-key + .fig-key::before { content: "\00b7"; margin-right: var(--spacing-12); color: var(--color-silver); }
.fig-key {
  font-size: var(--text-caption);
  letter-spacing: var(--tracking-caption);
  text-transform: uppercase;
  color: var(--color-steel);
  font-weight: var(--fw-medium);
}

/* The two proposed-mechanism spot illustrations, side by side under the diagram. */
/* The mechanism of action, as three panels: the disease state, then the two
   proposed mechanisms. Each panel is an image, a label, and its own evidence. */
.moa-steps { display: block; margin-top: var(--spacing-48); }
.moa-step {
  display: grid;
  grid-template-columns: minmax(0, 5fr) minmax(0, 7fr);
  gap: var(--spacing-40);
  align-items: start;
  margin: 0;
  padding-top: var(--spacing-24);
  border-top: 1px solid var(--color-ink-black);
}
.moa-step + .moa-step { margin-top: var(--spacing-48); }
.moa-step__media { margin: 0; }
.moa-step__label {
  display: block;
  font-size: var(--text-caption);
  letter-spacing: var(--tracking-caption);
  text-transform: uppercase;
  color: var(--color-steel);
  font-weight: var(--fw-medium);
}
.moa-step__title {
  margin-top: var(--spacing-4);
  font-size: var(--text-subheading);
  line-height: var(--leading-subheading);
  letter-spacing: var(--tracking-subheading);
  font-weight: var(--fw-medium);
}
.moa-list { margin-top: var(--spacing-20); padding-left: 0; list-style: none; max-width: 70ch; }
.moa-list li {
  position: relative;
  padding-left: var(--spacing-20);
  font-size: var(--text-body);
  line-height: var(--leading-body);
  letter-spacing: var(--tracking-body);
  color: var(--color-slate);
}
.moa-list li + li { margin-top: var(--spacing-12); }
.moa-list li::before {
  content: "";
  position: absolute;
  left: 0;
  top: 0.66em;
  width: 5px;
  height: 5px;
  background: var(--color-steel);
}
.moa-outcome {
  margin-top: var(--spacing-40);
  padding-top: var(--spacing-20);
  border-top: 1px solid var(--color-ink-black);
  font-size: var(--text-body);
  line-height: var(--leading-body);
  letter-spacing: var(--tracking-body);
  color: var(--color-ink-black);
  max-width: 84ch;
}
.chart-key {
  display: inline-flex;
  align-items: center;
  gap: var(--spacing-8);
  font-size: var(--text-body);
  letter-spacing: var(--tracking-body);
  color: var(--color-slate);
}
.chart-swatch { width: 20px; height: 8px; background: var(--color-ink-black); flex: none; }
.chart-swatch--study { background: var(--color-silver); }
.chart-swatch--lit { background: #c8cbd0; }

/* Cyclodextrin geometry diagram */
.geo { display: grid; grid-template-columns: 1fr 1fr; gap: var(--spacing-24); }
.geo__panel { margin: 0; }
.geo__svg { width: 100%; height: auto; color: var(--color-ink-black); display: block; }
.geo__panel { border: 1px solid var(--color-bone); padding: var(--spacing-20); }
.geo__panel figcaption { display: block; margin-top: var(--spacing-12); border-top: 1px solid var(--color-bone); padding-top: var(--spacing-12); }
.geo__title {
  display: block;
  font-size: var(--text-body);
  font-weight: var(--fw-medium);
  letter-spacing: var(--tracking-body);
  color: var(--color-ink-black);
}
.geo__body {
  display: block;
  margin-top: var(--spacing-4);
  font-size: var(--text-caption);
  line-height: 1.5;
  letter-spacing: var(--tracking-caption);
  color: var(--color-steel);
}


/* ---------- Chemistry and mechanism figures ---------- */
.chem-o { font-size: 11px; font-weight: 500; fill: var(--color-ink-black); }
.chem-l { font-size: 12px; fill: var(--color-slate); }
.chem-d { font-size: 12px; font-weight: 500; fill: var(--color-ink-black); }

/* ---------- List rows (filings, presentations, news) ---------- */
.rows { border-top: 1px solid var(--color-bone); }
.row {
  display: grid;
  grid-template-columns: 160px 1fr auto;
  gap: var(--spacing-24);
  align-items: baseline;
  padding-block: var(--spacing-24);
  border-bottom: 1px solid var(--color-bone);
}
.row__date { font-size: var(--text-caption); letter-spacing: var(--tracking-caption); text-transform: uppercase; color: var(--color-steel); font-weight: var(--fw-medium); }
.row__title { font-size: var(--text-subheading); line-height: var(--leading-subheading); letter-spacing: var(--tracking-subheading); font-weight: var(--fw-450); max-width: 720px; }
.row__action { font-size: 13px; font-weight: var(--fw-medium); white-space: nowrap; }
a.row:hover .row__title { color: var(--color-slate); }
a.row:hover .row__action { text-decoration: underline; text-underline-offset: 2px; }

/* Tag */
.tag {
  display: inline-block;
  border: 1px solid var(--color-bone);
  border-radius: var(--radius-tags);
  padding: 2px 8px;
  font-size: var(--text-caption);
  letter-spacing: var(--tracking-caption);
  text-transform: uppercase;
  color: var(--color-steel);
  font-weight: var(--fw-medium);
}

/* ---------- Stats ---------- */
.stats { display: grid; grid-template-columns: repeat(4, 1fr); gap: var(--spacing-24); }
.stat { border-top: 1px solid var(--color-ink-black); padding-top: var(--spacing-16); }
.stat__value { font-size: var(--text-heading); line-height: var(--leading-heading); letter-spacing: var(--tracking-heading); font-weight: var(--fw-regular); }
.stat__label { margin-top: var(--spacing-8); font-size: var(--text-body); color: var(--color-slate); letter-spacing: var(--tracking-body); }

/* ---------- Download block ---------- */
.download {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: var(--spacing-48);
  align-items: center;
  border: 1px solid var(--color-bone);
  padding: var(--spacing-24);
}
.download__body > * + * { margin-top: var(--spacing-16); }

/* ---------- Forms ---------- */
.form { display: grid; gap: var(--spacing-20); max-width: 560px; }
.field { display: grid; gap: var(--spacing-8); }
.field label { font-size: var(--text-caption); letter-spacing: var(--tracking-caption); text-transform: uppercase; color: var(--color-steel); font-weight: var(--fw-medium); }
.field input, .field select, .field textarea {
  font: inherit;
  font-size: var(--text-body-lg);
  color: var(--color-ink-black);
  background: var(--color-pure-white);
  border: 1px solid var(--color-bone);
  border-radius: var(--radius-inputs);
  padding: 10px 12px;
  width: 100%;
}
.field textarea { min-height: 140px; resize: vertical; }
.field input::placeholder, .field textarea::placeholder { color: var(--color-silver); }
.field input:focus, .field select:focus, .field textarea:focus { outline: 1px solid var(--color-ink-black); border-color: var(--color-ink-black); }
.form__actions { margin-top: var(--spacing-8); }

.contact-cols { display: grid; grid-template-columns: 1fr 1fr; gap: var(--spacing-80); align-items: start; }
.detail + .detail { margin-top: var(--spacing-28); }
.detail__label { font-size: var(--text-caption); letter-spacing: var(--tracking-caption); text-transform: uppercase; color: var(--color-steel); font-weight: var(--fw-medium); }
.detail__value { margin-top: var(--spacing-8); font-size: var(--text-body-lg); letter-spacing: var(--tracking-body-lg); }

/* ---------- Footer ---------- */
.footer { border-top: 1px solid var(--color-bone); padding-block: var(--spacing-64); margin-top: var(--spacing-96); }
.footer__cols { display: grid; grid-template-columns: 2fr 1fr 1fr 1fr; gap: var(--spacing-48); }
.footer__head { font-size: var(--text-caption); letter-spacing: var(--tracking-caption); text-transform: uppercase; color: var(--color-steel); font-weight: var(--fw-medium); margin-bottom: var(--spacing-16); }
.footer__cols a { display: block; font-size: var(--text-body); letter-spacing: var(--tracking-body); color: var(--color-slate); padding-block: var(--spacing-4); }
.footer__cols a:hover { color: var(--color-ink-black); }
.footer__base {
  display: flex;
  justify-content: space-between;
  gap: var(--spacing-24);
  flex-wrap: wrap;
  margin-top: var(--spacing-64);
  padding-top: var(--spacing-24);
  border-top: 1px solid var(--color-bone);
}
.footer__base .caption { text-transform: none; letter-spacing: var(--tracking-caption); }

/* ---------- Responsive ---------- */
@media (max-width: 1180px) {
  .nav__links { display: none; }
  .nav__toggle { display: inline-flex; }
  .nav__actions .link-ghost { display: none; }
  .leaders { grid-template-columns: repeat(2, 1fr); }
  .journey { grid-template-columns: repeat(2, 1fr); }
  .moa-step { grid-template-columns: minmax(0, 5fr) minmax(0, 7fr); gap: var(--spacing-28); }
  .stats { grid-template-columns: repeat(2, 1fr); }
  .footer__cols { grid-template-columns: 1fr 1fr; gap: var(--spacing-40); }
}

@media (max-width: 860px) {
  :root {
    --text-display: 36px;   --tracking-display: -0.9px;
    --text-heading-lg: 32px; --tracking-heading-lg: -0.77px;
    --text-heading: 28px;   --tracking-heading: -0.47px;
    --section-gap: 64px;
  }
  .hero { padding-top: var(--spacing-96); padding-bottom: var(--spacing-64); }
  .hero--after-media { padding-top: var(--spacing-48); padding-bottom: var(--spacing-64); }
  .media--hero {
    aspect-ratio: 4 / 3;
    min-height: 180px;
    max-height: calc(100vh - 300px);
    max-height: calc(100svh - 300px);
  }
  .grid-2, .grid-3, .grid-4 { grid-template-columns: 1fr; }
  .prose-2 { grid-template-columns: 1fr; gap: var(--spacing-20); }
  .split { grid-template-columns: 1fr; gap: var(--spacing-20); }
  .split__head h2 { max-width: none; }
  .journey { grid-template-columns: 1fr; gap: var(--spacing-28); margin-top: var(--spacing-40); }
  .feature { grid-template-columns: 1fr; gap: var(--spacing-28); padding-block: var(--spacing-48); }
  .feature--reverse .feature__media { order: 0; }
  .contact-cols { grid-template-columns: 1fr; gap: var(--spacing-48); }
  .download { grid-template-columns: 1fr; gap: var(--spacing-24); }
  .pipeline__head, .pipeline__row { grid-template-columns: 1fr; gap: var(--spacing-12); }
  .row { grid-template-columns: 1fr; gap: var(--spacing-8); }
  .compare { grid-template-columns: 1fr; }
  .bar { grid-template-columns: 1fr; gap: var(--spacing-8); }
  .bar__track { border-left: 0; }
  .bar__value { text-align: left; }
  .geo { grid-template-columns: 1fr; }
  .moa-step { grid-template-columns: 1fr; gap: var(--spacing-20); }
  .leaders { grid-template-columns: 1fr; }
  .leaders--text { grid-template-columns: 1fr; }
}

@media (max-width: 560px) {
  .nav .wrap { padding-inline: var(--spacing-20); }
  .stats { grid-template-columns: 1fr; }
  .footer__cols { grid-template-columns: 1fr; }
  .hero__actions { flex-direction: column; align-items: flex-start; gap: var(--spacing-16); }
}

/* ---------- Numbered steps list ---------- */
.steps-list { list-style: none; padding: 0; margin: 0; counter-reset: step; display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); grid-template-rows: repeat(4, auto); grid-auto-flow: column; gap: 0 var(--spacing-40); max-width: 900px; }
.steps-list li { counter-increment: step; display: flex; gap: var(--spacing-16); align-items: baseline; padding-block: var(--spacing-16); border-top: 1px solid var(--color-bone); font-size: var(--text-body); line-height: var(--leading-body); letter-spacing: var(--tracking-body); color: var(--color-ink-black); }
.steps-list li::before { content: counter(step, decimal-leading-zero); flex: none; width: 2ch; font-size: var(--text-caption); letter-spacing: var(--tracking-caption); color: var(--color-steel); font-weight: var(--fw-medium); }
@media (max-width: 720px) { .steps-list { grid-template-columns: 1fr; grid-template-rows: none; grid-auto-flow: row; } }

/* ---------- Overview flowchart ---------- */
.flow { margin-top: var(--spacing-48); display: grid; gap: var(--spacing-24); }
.flow__lane { border-top: 1px solid var(--color-ink-black); padding-top: var(--spacing-16); }
.flow__lane-label { font-size: var(--text-caption); letter-spacing: var(--tracking-caption); text-transform: uppercase; color: var(--color-steel); font-weight: var(--fw-medium); }
.flow__steps { list-style: none; margin: var(--spacing-16) 0 0; padding: 0; display: grid; grid-template-columns: repeat(4, minmax(0, 1fr)); gap: var(--spacing-24); }
.flow__step { position: relative; padding: var(--spacing-16); border: 1px solid var(--color-bone); background: #fff; font-size: var(--text-body); line-height: var(--leading-body); letter-spacing: var(--tracking-body); color: var(--color-slate); }
.flow__lane--drug .flow__step { border-color: var(--color-ink-black); color: var(--color-ink-black); }
.flow__step + .flow__step::before { content: "\2192"; position: absolute; left: calc(-1 * var(--spacing-24)); top: 50%; width: var(--spacing-24); transform: translateY(-50%); text-align: center; color: var(--color-silver); }
.flow__num { display: block; margin-bottom: var(--spacing-8); font-size: var(--text-caption); letter-spacing: var(--tracking-caption); color: var(--color-steel); font-weight: var(--fw-medium); }
.flow__result { padding: var(--spacing-16) var(--spacing-20); background: var(--color-ink-black); color: #fff; font-size: var(--text-body); letter-spacing: var(--tracking-body); }
@media (max-width: 860px) {
  .flow__steps { grid-template-columns: 1fr; gap: var(--spacing-20); }
  .flow__step + .flow__step::before { content: "\2193"; left: 50%; top: calc(-1 * var(--spacing-20)); width: auto; height: var(--spacing-20); transform: translateX(-50%); }
}

/* ---------- Numbered figure labels ---------- */
.fig-marks { position: absolute; inset: 0; width: 100%; height: 100%; pointer-events: none; }
.fig-marks circle { fill: var(--color-ink-black); stroke: #fff; stroke-width: 3; }
.fig-marks text { fill: #fff; font: 600 22px/1 var(--font-abcnormal); text-anchor: middle; }
.fig-legend { list-style: none; margin: var(--spacing-16) 0 0; padding: 0; display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: var(--spacing-8) var(--spacing-24); }
.fig-legend li { display: flex; gap: var(--spacing-8); align-items: baseline; font-size: var(--text-caption); line-height: 1.45; color: var(--color-slate); }
.fig-legend__n { flex: none; display: inline-grid; place-items: center; width: 18px; height: 18px; border-radius: 50%; background: var(--color-ink-black); color: #fff; font-size: 11px; font-weight: 600; }
.fig-legend--compact { grid-template-columns: 1fr; }
@media (max-width: 560px) { .fig-legend { grid-template-columns: 1fr; } }

/* ---------- Key-terms glossary ---------- */
.glossary { margin: var(--spacing-40) 0 0; max-width: 900px; display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: var(--spacing-16) var(--spacing-40); }
.glossary > div { border-top: 1px solid var(--color-bone); padding-top: var(--spacing-12); }
.glossary dt { font-size: var(--text-body); font-weight: var(--fw-medium); color: var(--color-ink-black); }
.glossary dd { margin: var(--spacing-4) 0 0; font-size: var(--text-caption); line-height: 1.5; color: var(--color-slate); }
@media (max-width: 560px) { .glossary { grid-template-columns: 1fr; } }